Henrik Walter
Director of the Research Division of Mind and Brain
Deputy Medical Director (Research) of the Department of Psychiatry and Clinical Neuroscience
Charite-Universitatsmedizin Berlin
Corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Berlin, Germany
The clinical utility of biomarker candidates identified in large cohorts will critically depend on their ability to predict outcomes in relevant patient cohorts. This talk will highlight strategies to address important challenges on this translational path, using results from our labs in biomarker research as an example, with primary focus on neuroimaging.
A particularly important task regarding clinical biomarker validation is the harmonization and standard­ization of data and analytic strategies across heterogeneous cohorts. To address this, we will present innovative tools and platforms, including HalfPipe, NBS-Predict and the web platform foldercase, as well as algorithms for multi-task-learning. Finally, we will give an overview on the clinical cohorts, which will be used for clinical validation in the environMental project.